ZCL 278 2-(4-Bromo-2-chlorophenoxy)-N-[[[4-[[(4,6-dimethyl-2-pyrimidinyl)amino]sulfonyl]phenyl]amino]thioxomethyl]acetamide

ZCL 278 2-(4-Bromo-2-chlorophenoxy)-N-[[[4-[[(4,6-dimethyl-2-pyrimidinyl)amino]sulfonyl]phenyl]amino]thioxomethyl]acetamide - Names and Identifiers

Name	ZCL278
Synonyms	ZCL278 ZCL 278 2-(4-Bromo-2-chlorophenoxy)-N-((4-(N-(4,6-dimethylpyrimidin-2-yl)sulfamoyl)phenyl)carbAmothioy 2-(4-broMo-2-chlorophenoxy)-N-(4-(N-(4,6-diMethylpyriMidin-2-yl)sulfaMoyl)phenylcarbaMothioyl)acetaMide 2-(4-Bromo-2-chlorophenoxy)-N-[[[4-[[(4,6-dimethyl-2-pyrimidinyl)amino]sulfonyl]phenyl]amino]thioxomethyl]acetamide 2-(4-Bromo-2-chlorophenoxy)-N-[[[4-[[(4,6-dimethyl-2-pyrimidinyl)amino]sulfonyl]phenyl]amino]thioxomethyl]acetamide ZCL278 ZCL 278 2-(4-Bromo-2-chlorophenoxy)-N-[[[4-[[(4,6-dimethyl-2-pyrimidinyl)amino]sulfonyl]phenyl]amino]thioxomethyl]acetamide
CAS	587841-73-4
EINECS	200-256-5

ZCL 278 2-(4-Bromo-2-chlorophenoxy)-N-[[[4-[[(4,6-dimethyl-2-pyrimidinyl)amino]sulfonyl]phenyl]amino]thioxomethyl]acetamide - Physico-chemical Properties

Molecular Formula	C21H19BrClN5O4S2
Molar Mass	584.89
Appearance	Light beige solid
Storage Condition	+2C to +8C
In vitro study	ZCL278 inhibits the activity of Cdc42 GTPase by competing with GTP, and shows a time-dependent relationship in the inhibition of Rac/Cdc42 phosphorylation. ZCL278 (50 μm) inhibits Cdc42-mediated microprojection formation, disrupting the GM130-linked Golgi structure in serum-starved Swiss 3T3 fibroblasts. ZCL278 was also able to inhibit Cdc42-mediated neuronal branching, growth cone kinetics and actin-mediated motor migration capacity in metastatic prostate cancer cell line PC-3 without cytotoxicity.

ZCL 278 2-(4-Bromo-2-chlorophenoxy)-N-[[[4-[[(4,6-dimethyl-2-pyrimidinyl)amino]sulfonyl]phenyl]amino]thioxomethyl]acetamide - Preparation solution concentration reference

	1mg	5mg	10mg
1 mM	0 ml	0 ml	0 ml
5 mM	0 ml	0 ml	0 ml
10 mM	0 ml	0 ml	0 ml
5 mM	0 ml	0 ml	0 ml

Last Update：2024-01-02 23:10:35

ZCL 278 2-(4-Bromo-2-chlorophenoxy)-N-[[[4-[[(4,6-dimethyl-2-pyrimidinyl)amino]sulfonyl]phenyl]amino]thioxomethyl]acetamide - Reference Information

biological activity

ZCL278 is a selective Cdc42 GTPase inhibitor with Kd of 11.4 μM.

in vitro study

ZCL278 inhibits the activity of Cdc42 GTPase by competing with GTP, showing a time-sensitive relationship in the inhibition of Rac/Cdc42 phosphorylation. ZCL278 (50 μM) inhibits Cdc42-mediated microprocess formation, disrupting the GM130-linked Golgi structure in serum-starved Swiss 3T3 fibroblasts. ZCL278 can also inhibit Cdc42-mediated neuronal branching, growth cone dynamics and actin-mediated motor migration in metastatic prostate cancer cell line PC-3, and has no cytotoxicity.

Last Update：2024-04-09 21:54:55

ZCL 278 2-(4-Bromo-2-chlorophenoxy)-N-[[[4-[[(4,6-dimethyl-2-pyrimidinyl)amino]sulfonyl]phenyl]amino]thioxomethyl]acetamide

Shanghai Yuanye Bio-Technology Co., Ltd.

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Product Name: ZCL278 Visit Supplier Webpage Request for quotation
CAS: 587841-73-4
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409

Wechat: 18301782025

Shanghai Yuanye Bio-Technology Co., Ltd.

Spot supply

Product Name: ZCL278 Visit Supplier Webpage Request for quotation
CAS: 587841-73-4
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409

Wechat: 18301782025

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ZCL 278 2-(4-Bromo-2-chlorophenoxy)-N-[[[4-[[(4,6-dimethyl-2-pyrimidinyl)amino]sulfonyl]phenyl]amino]thioxomethyl]acetamide

ZCL 278 2-(4-Bromo-2-chlorophenoxy)-N-[[[4-[[(4,6-dimethyl-2-pyrimidinyl)amino]sulfonyl]phenyl]amino]thioxomethyl]acetamide

ZCL278

CAS: 587841-73-4

Molecular Formula: C21H19BrClN5O4S2

ZCL 278 2-(4-Bromo-2-chlorophenoxy)-N-[[[4-[[(4,6-dimethyl-2-pyrimidinyl)amino]sulfonyl]phenyl]amino]thioxomethyl]acetamide - Names and Identifiers

ZCL 278 2-(4-Bromo-2-chlorophenoxy)-N-[[[4-[[(4,6-dimethyl-2-pyrimidinyl)amino]sulfonyl]phenyl]amino]thioxomethyl]acetamide - Physico-chemical Properties

ZCL 278 2-(4-Bromo-2-chlorophenoxy)-N-[[[4-[[(4,6-dimethyl-2-pyrimidinyl)amino]sulfonyl]phenyl]amino]thioxomethyl]acetamide - Preparation solution concentration reference

ZCL 278 2-(4-Bromo-2-chlorophenoxy)-N-[[[4-[[(4,6-dimethyl-2-pyrimidinyl)amino]sulfonyl]phenyl]amino]thioxomethyl]acetamide - Reference Information

Supplier List

ZCL 278 2-(4-Bromo-2-chlorophenoxy)-N-[[[4-[[(4,6-dimethyl-2-pyrimidinyl)amino]sulfonyl]phenyl]amino]thioxomethyl]acetamide Request for Quotation

ZCL278

CAS: 587841-73-4

Molecular Formula: C21H19BrClN5O4S2

ZCL 278 2-(4-Bromo-2-chlorophenoxy)-N-[[[4-[[(4,6-dimethyl-2-pyrimidinyl)amino]sulfonyl]phenyl]amino]thioxomethyl]acetamide - Names and Identifiers

ZCL 278 2-(4-Bromo-2-chlorophenoxy)-N-[[[4-[[(4,6-dimethyl-2-pyrimidinyl)amino]sulfonyl]phenyl]amino]thioxomethyl]acetamide - Physico-chemical Properties

ZCL 278 2-(4-Bromo-2-chlorophenoxy)-N-[[[4-[[(4,6-dimethyl-2-pyrimidinyl)amino]sulfonyl]phenyl]amino]thioxomethyl]acetamide - Preparation solution concentration reference

ZCL 278 2-(4-Bromo-2-chlorophenoxy)-N-[[[4-[[(4,6-dimethyl-2-pyrimidinyl)amino]sulfonyl]phenyl]amino]thioxomethyl]acetamide - Reference Information

Supplier List

ZCL 278 2-(4-Bromo-2-chlorophenoxy)-N-[[[4-[[(4,6-dimethyl-2-pyrimidinyl)amino]sulfonyl]phenyl]amino]thioxomethyl]acetamide